Anticonvulsant
Blocks voltage-gated sodium channels, stabilizing hyperexcited neural membranes and inhibiting repetitive neuronal firing.
Partial seizures, adjunctive therapy for generalized tonic-clonic seizures
Bipolar disorder, neuropathic pain, restless leg syndrome (RLS)
Tablets, oral suspension
300 mg p.o. twice daily, titrated based on clinical response and tolerability
600–2400 mg/day, though many patients respond within the 900–1500 mg/day range
Metabolized to active monohydroxy derivative; less CYP3A4 induction than carbamazepine; primarily renal excretion
Dizziness, somnolence, headache, nausea, hyponatremia
Hyponatremia, hypersensitivity reactions
Serum sodium levels, renal function, signs of hypersensitivity
None
Use with caution in elderly patients and those with dementia due to sedative effects and fall risk. Dose adjustments may be necessary in renal impairment. Oxcarbazepine may be used cautiously in individuals with developmental disabilities, especially when seizures or mood symptoms co-occur; careful monitoring is recommended due to sedation and electrolyte disturbance risks.